Wolbachia -Induced Neutrophil Activation in a Mouse Model of Ocular Onchocerciasis (River Blindness)
نویسندگان
چکیده
منابع مشابه
Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness).
Endosymbiotic Wolbachia bacteria are abundant in the filarial nematodes that cause onchocerciasis (river blindness), including the larvae (microfilariae) that migrate into the cornea. Using a mouse model of ocular onchocerciasis, we recently demonstrated that it is these endosymbiotic bacteria rather than the nematodes per se that induce neutrophil infiltration to the corneal stroma and loss of...
متن کاملOnchocerciasis--river blindness.
Onchocerciasis results from infestation by the nematode Onchocerca volvulus and is characterized by troublesome itching, skin lesions, and eye manifestations. Although partially controlled by international mass prevention programs, onchocerciasis remains a major health hazard and is endemic in Africa, Arabia, and the Americas. Onchocerciasis is spread by bites from infested black flies, which t...
متن کاملWolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis
The endosymbiotic bacteria, Wolbachia, induce neutrophilic responses to the human helminth pathogen Onchocerca volvulus. The formation of Neutrophil Extracellular Traps (NETs), has been implicated in anti-microbial defence, but has not been identified in human helminth infection. Here, we demonstrate NETs formation in human onchocerciasis. Extracellular NETs and neutrophils were visualised arou...
متن کاملCase 7: Controlling Onchocerciasis (River Blindness) in Sub-Saharan Africa
The first draft of this case was prepared by Jane Seymour and Molly Kinder; significant contributions to the current version were made by Bruce Benton. as in a prominent square in Ouagadougou, Burkina Faso, visitors see a distinctive statue of a child leading a blind man—a symbolic reminder to passersby of the part each partner played in the control of one of Africa’s most devastating diseases....
متن کاملWolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88.
Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2004
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.72.10.5687-5692.2004